

Feelings of helplessness and hopelessness | A bleak outlook—nothing will ever get better and there’s nothing you can do to improve your situation. |
Loss of interest in dailly activities | No interest in or ability to enjoy former hobbies, pastimes, social activities, or sex. |
Appetite or weight changes | Significant weight loss or weight gain—a change of more than 5% of body weight in a month. |
Sleep changes | Either insomnia or oversleeping (also known as hypersomnia). |
Psychomotor agitation or retardation | Either feeling “keyed up” and restless or sluggish and physically slowed down. |
Loss of energy | Feeling fatigued and physically drained. Even small tasks are exhausting or take longer. |
Self-loathing | Strong feelings of worthlessness or guilt. Harsh criticism of perceived faults and mistakes. |
Concentration problems | Trouble focusing, making decisions, or remembering things. |
Irritability | Easily annoyed or frustrated. Lashing out in anger or snapping at others. |
Aches and pains | New or worse physical symptoms, including headaches, backaches, diarrhea or constipation, abdominal pain, and aching joints. |